SCARB2 antibody (AA 48-357)

Catalog No. ABIN7875206

This Rabbit Polyclonal antibody specifically detects SCARB2 in WB, ELISA, IHC (p), FACS and IF. It exhibits reactivity toward Human.

Quick Overview for SCARB2 antibody (AA 48-357) (ABIN7875206)

Target: SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCARB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-SCARB2 Antibody

Binding Specificity: AA 48-357

Purpose: SR-BII Antibody / SCARB2 / LIMPII

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E48-H357) was used as the immunogen for the SR-BII antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SR-BII antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SR-BII antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SCARB2

Target: SCARB2 (Scavenger Receptor Class B, Member 2 (SCARB2))

Alternative Name: SR-BII

Background: Lysosomal integral membrane protein 2 (LIMP-2), also called Scavenger receptor class B member 2, is a protein that in humans is encoded by the SCARB2 gene. The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: Q14108