BIRC6 antibody (AA 4810-4844)

Catalog No. ABIN7875225

The Rabbit Polyclonal anti-BIRC6 antibody is suitable to detect BIRC6 in samples from Human. It has been validated for WB.

Quick Overview for BIRC6 antibody (AA 4810-4844) (ABIN7875225)

Target: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BIRC6 Antibody

Binding Specificity: AA 4810-4844

Purpose: BIRC6 Antibody (C-Terminal Region)

Purification: Antigen affinity

Immunogen: A portion of amino acids 4810-4844 from human BIRC6 was used as the immunogen for the BIRC6 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the BIRC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the BIRC6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for BIRC6

Target: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Alternative Name: BIRC6

Background: Baculoviral IAP repeat-containing protein 6 / APOLLON is an anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. [UniProt]

UniProt: Q9NR09