Peroxiredoxin 2 antibody (AA 5-127)

Catalog No. ABIN7875288

The Rabbit Polyclonal anti-Peroxiredoxin 2 antibody is suitable to detect Peroxiredoxin 2 in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for Peroxiredoxin 2 antibody (AA 5-127) (ABIN7875288)

Target: Peroxiredoxin 2 (PRDX2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Peroxiredoxin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Peroxiredoxin 2 Antibody

Binding Specificity: AA 5-127

Purpose: PRDX2 Antibody / Peroxiredoxin 2

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids N5-R127) was used as the immunogen for the PRDX2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PRDX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PRDX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Peroxiredoxin 2

Target: Peroxiredoxin 2 (PRDX2)

Alternative Name: PRDX2

Background: PRDX2 (Peroxiredoxin 2) also known as NKEFB, PRP, PRX2, PRXII or TPX1, is a protein that in humans is encoded by the PRDX2 gene. This gene encodes a member of the peroxiredoxin family of anti-oxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The Prdx2-/- mice were healthy in appearance and fertile. Choi et al.(2005) demonstrated that PRDX2 is a negative regulator of PDGF signaling. Prx II deficiency results in increased production of peroxide, enhanced activation of PDGF receptor and phospholipase C-gamma-1, and subsequently increased cell proliferation and migration in response to PDGF. PRX2 accounted for about half of the thioredoxin activity in parasite extracts, and PRX2 expression was increased in the presence of chloroquine, regardless of P. falciparum strain susceptibility to the drug.

UniProt: P32119