SOX11 antibody (AA 50-200)

Catalog No. ABIN7875329

This Mouse Monoclonal antibody specifically detects SOX11 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for SOX11 antibody (AA 50-200) (ABIN7875329)

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOX11 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: SOX11-7236

Product Details anti-SOX11 Antibody

Binding Specificity: AA 50-200

Purpose: SOX11 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 50-200 was used as the immunogen for the SOX11 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the SOX11 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the SOX11 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SOX11

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Alternative Name: SOX11

Background: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

UniProt: P35716

Pathways: Tube Formation