TAO Kinase 2 antibody (AA 502-1142)

Catalog No. ABIN7875490

The Rabbit Polyclonal anti-TAO Kinase 2 antibody (ABIN7875490) specifically detects TAO Kinase 2 in WB, ELISA, IHC, IF and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TAO Kinase 2 antibody (AA 502-1142) (ABIN7875490)

Target: TAO Kinase 2 (TAOK2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAO Kinase 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-TAO Kinase 2 Antibody

Binding Specificity: AA 502-1142

Purpose: TAOK2 Antibody / TAO kinase 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TAOK2 recombinant protein (Position: H502-H1142) was used as the immunogen for the TAOK2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TAOK2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TAOK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TAO Kinase 2

Target: TAO Kinase 2 (TAOK2)

Alternative Name: TAOK2

Background: TAOK2 antibody recognizes TAO kinase 2, a serine/threonine-protein kinase encoded by the TAOK2 gene, which functions as an upstream activator in multiple MAPK signaling cascades. TAOK2 (Thousand And One Kinase 2) belongs to the STE20 kinase family and regulates cytoskeletal dynamics, stress response pathways, and neuronal development. The kinase localizes to both the cytoplasm and centrosomes, where it phosphorylates downstream kinases such as MAP2K3 and MAP2K6 to activate p38 MAPK signaling. Through these pathways, TAOK2 influences apoptosis, differentiation, and responses to cellular stress.

TAOK2 plays a critical role in neuronal morphology and synaptic function. It regulates microtubule stability and axon elongation through phosphorylation of cytoskeletal proteins, including microtubule-associated proteins. In developing neurons, TAOK2 helps establish dendritic spine structure and connectivity, contributing to proper neural circuit formation. Mutations and deletions of TAOK2 have been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia, underscoring its importance in brain development. Studies show that TAOK2 interacts with autism risk proteins including SHANK1 and DISC1 and modulates signaling through Rho GTPases and JNK kinases.

The TAOK2 gene is located on chromosome 16p11.2, a genomic region frequently associated with copy number variations implicated in neurodevelopmental conditions. TAOK2 exists in several alternatively spliced isoforms with distinct subcellular localization and regulatory functions. The full-length protein contains an N-terminal kinase domain and a C-terminal coiled-coil domain that mediates protein-protein interactions. TAOK2 activation can be induced by oxidative stress, UV radiation, or cytokine stimulation, linking it to broader cellular stress responses and apoptosis regulation.

Immunohistochemical staining using TAOK2 antibody shows expression in brain tissue, particularly in the cortex and hippocampus, as well as in heart and testis. It has been used to study MAPK pathway signaling, neuronal cytoskeleton remodeling, and stress-induced apoptosis. TAOK2 antibody from NSJ Bioreagents is a valuable tool for investigating kinase-mediated signal transduction, neuronal development, and neuropsychiatric disease mechanisms.

UniProt: Q9UL54

Pathways: Cell-Cell Junction Organization