COX2 antibody (AA 504-604)

Catalog No. ABIN7875494

This Mouse Monoclonal antibody specifically detects COX2 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for COX2 antibody (AA 504-604) (ABIN7875494)

Target: COX2 (Cytochrome C Oxidase Subunit II (COX2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COX2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RCOX2-6996

Product Details anti-COX2 Antibody

Binding Specificity: AA 504-604

Purpose: COX2 Antibody / Cyclooxygenase 2 / PTGS2

Purification: Protein A/G affinity

Immunogen: A recombinant human COX2 protein fragment (within amino acids 504-604) was used as the immunogen for the COX2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the COX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the COX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for COX2

Target: COX2 (Cytochrome C Oxidase Subunit II (COX2))

Alternative Name: COX2

Background: Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90 % of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.

UniProt: P35354

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation