LHCGR antibody (AA 51-708)

Catalog No. ABIN7875523

The Rabbit Polyclonal anti-LHCGR antibody (ABIN7875523) specifically detects LHCGR in IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for LHCGR antibody (AA 51-708) (ABIN7875523)

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LHCGR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LHCGR Antibody

Binding Specificity: AA 51-708

Purpose: Zebrafish Lhcgr Antibody / Lutropin-choriogonadotropic hormone receptor

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Lhcgr recombinant protein (amino acids V51-V708) was used as the immunogen for the Zebrafish Lhcgr antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Lhcgr antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Lhcgr antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LHCGR

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Alternative Name: Lhcgr

Background: Luteinizing hormone/choriogonadotropin receptor (Lhcgr) is a G protein-coupled receptor that mediates the actions of luteinizing hormone (LH) and chorionic gonadotropin (CG). In zebrafish (Danio rerio), Lhcgr plays a crucial role in gonadal development and function, including steroidogenesis, oocyte maturation, and ovulation.

Zebrafish lhcgr is primarily expressed in the gonads, where it facilitates LH signaling necessary for reproductive maturation and fertility. Activation of Lhcgr triggers downstream signaling cascades, including cAMP/PKA pathways, leading to the production of sex steroids such as estradiol and testosterone. Functional studies in zebrafish have shown that Lhcgr is essential for proper follicular development and ovulation in females, and for Leydig cell function in males.

As a conserved reproductive hormone receptor, zebrafish Lhcgr is a valuable model for investigating vertebrate reproductive endocrinology, hormone receptor signaling, and the genetic basis of fertility and gonadal disorders.

UniProt: Q6TCF8

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling