HAAO antibody (AA 52-286)

Catalog No. ABIN7875557

This Rabbit Polyclonal antibody specifically detects HAAO in WB, ELISA and IF. It exhibits reactivity toward Human and Rat.

Quick Overview for HAAO antibody (AA 52-286) (ABIN7875557)

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAAO antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-HAAO Antibody

Binding Specificity: AA 52-286

Purpose: HAAO Antibody / 3-hydroxyanthranilate 3, 4-dioxygenase / 3HAO

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids E52-G286) was used as the immunogen for the HAAO antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HAAO antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the HAAO Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HAAO

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Alternative Name: HAAO

Background: 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

UniProt: P46952