ORMDL3 antibody (AA 53-81)

Catalog No. ABIN7875600

The Rabbit Polyclonal anti-ORMDL3 antibody is suitable to detect ORMDL3 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for ORMDL3 antibody (AA 53-81) (ABIN7875600)

Target: ORMDL3 (ORM1-Like 3 (ORMDL3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORMDL3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ORMDL3 Antibody

Binding Specificity: AA 53-81

Purpose: ORMDL3 Antibody / ORM1-like protein 3

Purification: Antigen affinity

Immunogen: A portion of amino acids 53-81 from the human protein was used as the immunogen for the ORMDL3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the ORMDL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ORMDL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ORMDL3

Target: ORMDL3 (ORM1-Like 3 (ORMDL3))

Alternative Name: ORMDL3

Background: ORM1-like protein 3 is a protein that is encoded by the ORMDL3 gene. It belongs to a family of proteins known as ORM proteins, which play a crucial role in regulating the levels of sphingolipids - a class of lipids that are involved in various cellular processes. In particular, ORMDL3 has been shown to be a key player in the regulation of sphingolipid synthesis, and aberrant expression of this protein has been implicated in a number of diseases, including asthma. Recent studies have revealed that ORMDL3 plays a critical role in the development of asthma. It has been shown that individuals with certain genetic variations that result in increased ORMDL3 expression are at a higher risk of developing asthma. Additionally, ORMDL3 has been shown to be involved in the regulation of immune responses in the lungs, with increased levels of this protein leading to inflammation and airway hyperreactivity - hallmark features of asthma.

UniProt: Q8N138