Exportin 2 antibody (AA 55-84)

Catalog No. ABIN7875700

The Rabbit Polyclonal anti-Exportin 2 antibody (ABIN7875700) specifically detects Exportin 2 in WB, IF and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for Exportin 2 antibody (AA 55-84) (ABIN7875700)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Exportin 2 Antibody

Binding Specificity: AA 55-84

Purpose: Exportin 2 Antibody / CSE1L

Purification: SAS precipitation

Immunogen: A portion of amino acids 55-84 from the human protein was used as the immunogen for the Exportin 2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Exportin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Exportin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: Exportin 2

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.

UniProt: P55060

Pathways: Protein targeting to Nucleus