Emerin antibody (AA 56-167)

Catalog No. ABIN7875760

The Mouse Monoclonal anti-Emerin antibody (Clone EMD-2167) (ABIN7875760) specifically detects Emerin in WB, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Emerin antibody (AA 56-167) (ABIN7875760)

Target: Emerin (EMD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Emerin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: EMD-2167

Product Details anti-Emerin Antibody

Binding Specificity: AA 56-167

Purpose: Emerin Antibody

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 56-167 from the human protein was used as the immunogen for the Emerin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Titering of the Emerin antibody may be required for optimal performance.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Emerin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Emerin

Target: Emerin (EMD)

Alternative Name: Emerin

Background: Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.

UniProt: P50402