LDHD antibody (AA 56-498)

Catalog No. ABIN7875771

The Rabbit Polyclonal anti-LDHD antibody is suitable to detect LDHD in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for LDHD antibody (AA 56-498) (ABIN7875771)

Target: LDHD (Lactate Dehydrogenase D (LDHD))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDHD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-LDHD Antibody

Binding Specificity: AA 56-498

Purpose: LDHD Antibody / D-lactate dehydrogenase

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids R56-Q498) was used as the immunogen for the LDHD antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LDHD antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LDHD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LDHD

Target: LDHD (Lactate Dehydrogenase D (LDHD))

Alternative Name: LDHD

Background: Two naturally occurring forms of lactate dehydrogenase with similar but unique substrate specificities have been isolated in lower organisms including invertebrates, fungi, and prokaryotes. These dehydrogenase enzymes are L-lactate dehydrogenase and D-lactate dehydrogenase (LDHD) that are specific to the L and D isomers of lactate, respectively (PMID: 12127981). In lactic acid bacteria, LDHD plays a key role in anaerobic energy metabolism (PMID: 497162). Despite the identification of D-lactate and other D-2-hydroxyacids in prokaryotes, and the obvious connections and similarities to vertebrate metabolic pathways, very few mammalian D-2-hydroxyacid dehydrogenases have been found. LDHD has 2 isoforms with the molecular weight of 52 and 54 kDa, and can be detected as 45-54 kDa.

UniProt: Q86WU2

Pathways: Ribonucleoside Biosynthetic Process