C1S antibody (AA 560-589)

Catalog No. ABIN7875782

This Rabbit Polyclonal antibody specifically detects C1S in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for C1S antibody (AA 560-589) (ABIN7875782)

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1S antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-C1S Antibody

Binding Specificity: AA 560-589

Purpose: C1S Antibody / Complement C1s subcomponent

Immunogen: A portion of amino acids 560-589 from the human protein was used as the immunogen for the C1S antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the C1S antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide and 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the C1S antibody at -20oC.

Target Details for C1S

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Alternative Name: C1S

Background: C1S, also called Complement C1s subcomponent, is a serine protease enzyme that plays a significant role in the activation of the Complement system, which is a part of the innate immune system. C1S is a key component of the C1 complex, which is the first step in the Complement activation cascade. One of the main functions of C1S is to cleave C4 and C2 proteins, leading to the formation of the C3 convertase enzyme. This enzyme then cleaves C3 protein into two parts, C3a and C3b, which mediate various immune responses such as inflammation, opsonization, and cell lysis. Overall, the activation of the Complement system through C1S plays a critical role in enhancing the immune response and clearing pathogens from our bodies. In addition to its role in immune defense, C1S has also been implicated in other physiological processes such as inflammation, tissue repair, and development. Dysregulation of C1S activity has been linked to various diseases, including autoimmune disorders, inflammatory conditions, and infectious diseases.

UniProt: P09871

Pathways: Complement System