STOX2 antibody (AA 57-659)

Catalog No. ABIN7875810

The Rabbit Polyclonal anti-STOX2 antibody is suitable to detect STOX2 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for STOX2 antibody (AA 57-659) (ABIN7875810)

Target: STOX2 (Storkhead Box 2 (STOX2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STOX2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-STOX2 Antibody

Binding Specificity: AA 57-659

Purpose: STOX2 Antibody / Storkhead box protein 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human STOX2 recombinant protein (Position: D57-K659) was used as the immunogen for the STOX2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STOX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STOX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STOX2

Target: STOX2 (Storkhead Box 2 (STOX2))

Alternative Name: STOX2

Background: STOX2 antibody detects Storkhead box protein 2, a nuclear transcription factor encoded by the STOX2 gene located on chromosome 4q35.1. STOX2 belongs to the storkhead box protein family, characterized by winged-helix (forkhead-like) DNA-binding domains, and functions primarily in transcriptional regulation during embryonic development and placental differentiation. It is expressed in brain, placenta, and reproductive tissues, with developmental expression patterns suggesting a key role in early organogenesis and epithelial cell specification.

STOX2 regulates gene networks involved in cell differentiation, extracellular matrix formation, and immune modulation. As a nuclear transcription factor, it binds promoter and enhancer regions to modulate expression of developmental and hormonal response genes. STOX2 expression increases during embryogenesis and trophoblast development, indicating a function in maternal-fetal interface establishment. In adult tissues, it remains expressed in epithelial and endothelial cells, maintaining homeostasis and tissue-specific gene expression.

Structurally, STOX2 contains a winged-helix DNA-binding domain typical of forkhead-like transcription factors, along with transactivation domains in its C-terminus that recruit transcriptional coactivators. It belongs to the storkhead box protein family, which includes STOX1i 1/2a transcription factor associated with preeclampsiai 1/2highlighting shared regulatory mechanisms in placental and vascular development. STOX2 may co-localize with transcriptional regulators such as SMADs in TGF-beta signaling, influencing epithelial differentiation and growth factor response.

Functionally, STOX2 contributes to placental morphogenesis and vascular remodeling. Its regulatory role in epithelial-mesenchymal transitions (EMT) and matrix deposition suggests involvement in tissue remodeling and wound repair. STOX2 may also modulate immune tolerance mechanisms at the maternal-fetal interface, ensuring proper placental development. In the nervous system, developmental expression studies show STOX2 activity during neuronal lineage specification, indicating broader roles beyond placentation.

Dysregulation of STOX2 expression has been associated with pregnancy-related disorders such as preeclampsia and intrauterine growth restriction. Aberrant promoter methylation or altered transcriptional regulation can disrupt placental gene networks. In cancer, reduced STOX2 levels have been linked to loss of epithelial integrity, while overexpression may contribute to tumor invasion through EMT activation. Pathway associations include TGF-beta signaling, Wnt signaling, and gene regulatory pathways governing developmental morphogenesis.

STOX2 antibody from NSJ Bioreagents serves as a reliable tool for investigating developmental transcriptional regulation, placental biology, and disease mechanisms involving epithelial differentiation.

UniProt: Q9P2F5