GLDC antibody (AA 574-1020)

Catalog No. ABIN7875824

This Rabbit Polyclonal antibody specifically detects GLDC in WB, ELISA, IHC (p) and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GLDC antibody (AA 574-1020) (ABIN7875824)

Target: GLDC (Glycine Dehydrogenase (GLDC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLDC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-GLDC Antibody

Binding Specificity: AA 574-1020

Purpose: Glycine decarboxylase Antibody

Purification: Affinity purified

Immunogen: A human recombinant partial protein (amino acids K574-S1020) was used as the immunogen for the Glycine decarboxylase antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Glycine decarboxylase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Glycine decarboxylase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GLDC

Target: GLDC (Glycine Dehydrogenase (GLDC))

Alternative Name: Glycine decarboxylase

Background: Glycine decarboxylase also known as glycine cleavage system P protein or glycine dehydrogenase is an enzyme that in humans is encoded by the GLDC gene. Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).

UniProt: P23378