GAR1 antibody (AA 58-165)

Catalog No. ABIN7875836

This Rabbit Polyclonal antibody specifically detects GAR1 in WB, IF, FACS, IP and IHC (p). It exhibits reactivity toward Human.

Quick Overview for GAR1 antibody (AA 58-165) (ABIN7875836)

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GAR1 Antibody

Binding Specificity: AA 58-165

Purpose: GAR1 Antibody / H/ACA ribonucleoprotein complex subunit 1 / NOLA1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids F58-K165) was used as the immunogen for the GAR1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GAR1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GAR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GAR1

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Alternative Name: GAR1

Background: GAR1 (H/ACA ribonucleoprotein complex subunit 1) is a highly conserved nucleolar protein that functions as an essential component of the H/ACA small nucleolar ribonucleoprotein (snoRNP) complex. This complex guides site-specific pseudouridylation of ribosomal RNA, a critical modification for ribosome biogenesis and proper protein synthesis.

GAR1 interacts with other snoRNP core proteins, including DKC1, NOP10, and NHP2, to ensure stability and catalytic activity of the H/ACA complex. Beyond its role in rRNA processing, GAR1 has been implicated in telomerase function and the regulation of RNA stability. Disruption of GAR1 activity has been associated with ribosomopathies and defects in cellular proliferation.

Using a high-quality GAR1 antibody enables accurate detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A GAR1 antibody from NSJ Bioreagents provides sensitivity and reproducibility for research in RNA modification, ribosome assembly, and nucleolar biology. Selecting the right GAR1 antibody is essential for generating reliable and consistent results.

UniProt: Q9NY12