FTH1 antibody (AA 58-180)

Catalog No. ABIN7875839

This Mouse Monoclonal antibody specifically detects FTH1 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for FTH1 antibody (AA 58-180) (ABIN7875839)

Target: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FTH1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: FTH-2081

Product Details anti-FTH1 Antibody

Binding Specificity: AA 58-180

Purpose: FTH1 Antibody / Ferritin heavy chain (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A human recombinant partial protein (amino acids 58-180) were used as the immunogen for the FTH1 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the FTH1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the FTH1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for FTH1

Target: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Alternative Name: FTH1

Background: Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts.

UniProt: P02794

Pathways: Transition Metal Ion Homeostasis