Recombinant Ferritin antibody (Heavy Chain)

Catalog No. ABIN7875841

The Rabbit Monoclonal anti-Ferritin antibody (Clone FTH-8700R) (ABIN7875841) specifically detects Ferritin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Ferritin antibody (Heavy Chain) (ABIN7875841)

Target: Ferritin (FE)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Ferritin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: FTH-8700R

Product Details anti-Ferritin Antibody

Binding Specificity: AA 58-180, Heavy Chain

Purpose: Recombinant Ferritin Heavy Chain Antibody / FTH1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant human FTH1 protein fragment (within amino acids 58-180) was used as the immunogen for the recombinant Ferritin Heavy Chain antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Ferritin Heavy Chain antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant Ferritin Heavy Chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Ferritin

Target: Ferritin (FE)

Alternative Name: Ferritin

Background: Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts.

UniProt: P02794

Pathways: Transition Metal Ion Homeostasis