ADRBK2 antibody (AA 591-688)

Catalog No. ABIN7875917

This Rabbit Polyclonal antibody specifically detects ADRBK2 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ADRBK2 antibody (AA 591-688) (ABIN7875917)

Target: ADRBK2 (Adrenergic, Beta, Receptor Kinase 2 (ADRBK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRBK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ADRBK2 Antibody

Binding Specificity: AA 591-688

Purpose: ADRBK2 Antibody / Beta-ARK-2 / GRK3

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R591-L688) was used as the immunogen for the ADRBK2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ADRBK2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ADRBK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ADRBK2

Target: ADRBK2 (Adrenergic, Beta, Receptor Kinase 2 (ADRBK2))

Alternative Name: ADRBK2

Background: Beta-adrenergic receptor kinase 2 (beta-ARK-2), also known as G-protein-coupled receptor kinase 3 (GRK3), is an enzyme that in humans is encoded by theADRBK2gene. The human ADRBK2 gene is located on 22q11. The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85 % amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95 % similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.

UniProt: P35626

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling