APOH antibody (AA 592-689)

Catalog No. ABIN7875928

The Mouse Monoclonal anti-APOH antibody (Clone APOH-3705) (ABIN7875928) specifically detects APOH in IHC (p). The antibody is reactive with Human samples.

Quick Overview for APOH antibody (AA 592-689) (ABIN7875928)

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOH antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: APOH-3705

Product Details anti-APOH Antibody

Binding Specificity: AA 592-689

Purpose: APOH Antibody / Apolipoprotein H

Purification: Protein A/G affinity

Immunogen: A human recombinant Apolipoprotein H protein fragment (within amino acids 592-689) was used as the immunogen for the APOH antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the APOH antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the APOH antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for APOH

Target: APOH (Apolipoprotein H (Beta-2-Glycoprotein I) (APOH))

Alternative Name: APOH

Background: Human apolipoprotein H (apoH, also designated b2-glycoprotein I, activated protein C binding protein or APC inhibitor) is a five-domain plasma membrane-adhesion protein that is rich in sialic acid linked a to galactose or N-acetylgal-actosamine. apoH has been implicated in a variety of physiological pathways, including blood coagulation and the immune response. apoH is a cofactor for the binding of serum auto-antibodies from antiphospholipid syndrome, and is correlated with thrombosis, lupus erythematosus and recurrent fetal loss. In addition, apoH is also implicated in the clearance of apoptotic bodies from the circulation. The apoH gene is located on human chromosome 17q24.2. apoH is synthesized by hepatocytes and is present in blood associated with plasma lipoproteins. apoH displays a genetically determined structural polymorphism including three alleles (apoH*1, apoH*2 and apoH*3). apoH can inhibit the translocation of cholesterol from extracellular pools to macrophages, which reduces the cellular accumulation of cholesterol, suggesting that apoH may play an important role in the prevention of atherosclerosis.

UniProt: P02749