MCM8 antibody (AA 598-840)

Catalog No. ABIN7875936

The Rabbit Polyclonal anti-MCM8 antibody is suitable to detect MCM8 in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for MCM8 antibody (AA 598-840) (ABIN7875936)

Target: MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MCM8 Antibody

Binding Specificity: AA 598-840

Purpose: MCM8 Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids N598-M840) was used as the immunogen for the MCM8 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MCM8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MCM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MCM8

Target: MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))

Alternative Name: MCM8

Background: DNA replication licensing factor MCM8 is a protein that in humans is encoded by the MCM8 gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. And this protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

UniProt: Q9UJA3

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA