OCIAD2 antibody (AA 6-138)

Catalog No. ABIN7875939

The Rabbit Polyclonal anti-OCIAD2 antibody is suitable to detect OCIAD2 in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for OCIAD2 antibody (AA 6-138) (ABIN7875939)

Target: OCIAD2 (OCIA Domain Containing 2 (OCIAD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OCIAD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-OCIAD2 Antibody

Binding Specificity: AA 6-138

Purpose: OCIAD2 Antibody / OCIA domain containing 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human OCIAD2 recombinant protein (Position: A6-K138) was used as the immunogen for the OCIAD2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the OCIAD2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the OCIAD2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for OCIAD2

Target: OCIAD2 (OCIA Domain Containing 2 (OCIAD2))

Alternative Name: OCIAD2

Background: OCIAD2 antibody detects OCIA domain-containing protein 2, encoded by the OCIAD2 gene on chromosome 4q31.21. OCIAD2 antibody is widely used in cancer biology, mitochondrial research, and developmental studies. OCIAD2 is a mitochondrial inner membrane protein implicated in oxidative phosphorylation regulation and cell signaling. It has been studied for its roles in ovarian cancer and other malignancies, where it influences tumor progression and chemoresistance.

Structurally, OCIAD2 is a ~17 kDa protein with a conserved OCIA domain mediating protein-protein interactions. It localizes to mitochondria and interacts with components of the respiratory chain. OCIAD2 may also associate with signaling molecules, linking mitochondrial metabolism with cell signaling pathways. Multiple isoforms may provide tissue-specific functions.

Functionally, OCIAD2 regulates mitochondrial activity by modulating electron transport chain components, influencing ATP production and reactive oxygen species generation. It has also been implicated in cell adhesion, proliferation, and survival. Researchers use OCIAD2 antibody to study mitochondrial function, cancer biology, and signaling networks.

Clinically, OCIAD2 is overexpressed in ovarian, lung, and breast cancers, correlating with poor prognosis and chemoresistance. It is being investigated as a biomarker of malignancy and as a therapeutic target. NSJ Bioreagents provides OCIAD2 antibody for studies of mitochondrial biology, cancer progression, and therapeutic development.

Experimentally, OCIAD2 antibody is used in western blotting to detect the ~17 kDa protein, in immunofluorescence to study mitochondrial localization, and in immunohistochemistry to analyze tumor expression. Co-immunoprecipitation with OCIAD2 antibody helps identify mitochondrial and signaling partners.

UniProt: Q56VL3