HHEX antibody (AA 60-228)

Catalog No. ABIN7875990

The Rabbit Polyclonal anti-HHEX antibody is suitable to detect HHEX in samples from Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for HHEX antibody (AA 60-228) (ABIN7875990)

Target: HHEX (Hematopoietically Expressed Homeobox (HHEX))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HHEX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HHEX Antibody

Binding Specificity: AA 60-228

Purpose: Zebrafish Hhex Antibody / Hex / Hematopoietically expressed homeobox protein

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Hhex recombinant protein (amino acids Y60-L228) was used as the immunogen for the Zebrafish Hhex antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Hhex antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Hhex antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HHEX

Target: HHEX (Hematopoietically Expressed Homeobox (HHEX))

Alternative Name: Hhex

Background: Hhex, or hematopoietically expressed homeobox, is a transcription factor that plays a critical role in early embryonic development, especially in the formation of the forebrain, thyroid, liver, and pancreas. In zebrafish, Hhex is essential for the specification and differentiation of endodermal and anterior mesodermal tissues.

Hhex is expressed early in the developing embryo, particularly in regions that give rise to the anterior foregut and associated organs. It regulates the expression of key developmental genes involved in organogenesis and is required for proper morphogenesis of the thyroid gland and liver. In the developing brain, Hhex also contributes to the patterning of forebrain structures.

Loss of Hhex function in zebrafish leads to defects in anterior endoderm formation, impaired thyroid and liver development, and abnormalities in forebrain organization. Because of its conserved function in vertebrate development, zebrafish Hhex serves as a valuable model for understanding congenital organ defects, endodermal lineage specification, and early tissue patterning.

Zebrafish Hhex is widely used in developmental biology, stem cell research, and disease modeling, particularly in studies focused on endocrine and hepatic organ development.

UniProt: Q9IAV3