STK33 antibody (AA 60-429)

Catalog No. ABIN7875995

This Rabbit Polyclonal antibody specifically detects STK33 in WB, ELISA, IHC, IF, ICC and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for STK33 antibody (AA 60-429) (ABIN7875995)

Target: STK33 (serine/threonine Kinase 33 (STK33))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK33 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-STK33 Antibody

Binding Specificity: AA 60-429

Purpose: STK33 Antibody / Serine/threonine-protein kinase 33

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human STK33 recombinant protein (Position: K60-Q429) was used as the immunogen for the STK33 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STK33 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STK33 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STK33

Target: STK33 (serine/threonine Kinase 33 (STK33))

Alternative Name: STK33

Background: The STK33 antibody targets Serine/threonine-protein kinase 33, a cytoplasmic kinase encoded by the STK33 gene. Serine/threonine-protein kinase 33 phosphorylates cytoskeletal and signaling proteins to regulate apoptosis, spermatogenesis, and metabolic processes. Although its precise substrates remain under investigation, STK33 is involved in kinase cascades that control cell survival and stress adaptation. The STK33 antibody enables researchers to explore kinase signaling, protein phosphorylation, and pathways relevant to oncogenesis and germ-cell differentiation.

Serine/threonine-protein kinase 33 belongs to the calcium/calmodulin-dependent kinase superfamily and contains a conserved catalytic domain typical of serine/threonine kinases. It localizes mainly in the cytoplasm but may associate with actin filaments and mitochondria under stress conditions. The STK33 antibody allows localization analysis to assess how cellular context affects its distribution and activity. In germ cells, STK33 plays a role in sperm flagellum assembly and maturation, supporting reproductive function.

Aberrant activation of Serine/threonine-protein kinase 33 has been associated with tumor progression in various cancers, including leukemia, glioma, and pancreatic carcinoma. The STK33 antibody supports research into these roles by enabling detection of protein levels in tumor tissues and evaluating the impact of genetic silencing or kinase inhibition. Some studies have suggested STK33 as a synthetic lethal partner with KRAS mutations, linking it to targeted cancer therapy exploration.

Beyond oncology, Serine/threonine-protein kinase 33 contributes to cytoskeletal organization and stress responses. It may phosphorylate structural proteins that stabilize actin networks and maintain cellular morphology. The STK33 antibody enables analysis of these cytoskeletal effects and supports biochemical assays aimed at identifying STK33 substrates and binding partners. Its expression has also been noted in cardiac and skeletal muscle, indicating a potential role in contractile function.

The STK33 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, displaying cytoplasmic staining consistent with its kinase activity. NSJ Bioreagents provides this antibody as a validated reagent for use in molecular biology, oncology, and developmental studies. By supporting detailed analysis of Serine/threonine-protein kinase 33, the STK33 antibody advances understanding of kinase signaling, cytoskeletal regulation, and disease mechanisms related to cellular stress and proliferation.

UniProt: Q9BYT3