Recombinant L1CAM antibody (AA 600-900)

Catalog No. ABIN7876057

The Rabbit Monoclonal anti-L1CAM antibody (Clone L1CAM-13053R) (ABIN7876057) specifically detects L1CAM in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant L1CAM antibody (AA 600-900) (ABIN7876057)

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This L1CAM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: L1CAM-13053R

Product Details anti-L1CAM Antibody

Binding Specificity: AA 600-900

Purpose: Neural cell adhesion molecule L1 Antibody / NCAM-L1

Purification: Protein A affinity

Immunogen: A portion of amino acids 600-900 from human L1CAM protein was used as the immunogen for the Neural cell adhesion molecule L1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Neural cell adhesion molecule L1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Neural cell adhesion molecule L1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for L1CAM

Target: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Alternative Name: Neural cell adhesion molecule L1

Background: L1 (L1 cell adhesion molecule) also known as CAML1, CD171, and HSAS is an adhesion molecule which plays an important role in the nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). This mouse monoclonal antibody recognizes the sequence immediately NH2-terminal to the tyrosine-based motif and binds L1 only when Y1176 is dephosphorylated. Phosphorylation of either T1172 or Y1176 strongly inhibits binding of 74-5H7 to the L1 cytoplasmic domain.

UniProt: P32004

Pathways: Synaptic Membrane