Calpain 3 antibody (AA 603-632)

Catalog No. ABIN7876071

The Rabbit Polyclonal anti-Calpain 3 antibody is suitable to detect Calpain 3 in samples from Human. It has been validated for WB, FACS and IHC (p).

Quick Overview for Calpain 3 antibody (AA 603-632) (ABIN7876071)

Target: Calpain 3 (CAPN3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Calpain 3 Antibody

Binding Specificity: AA 603-632

Purpose: CAPN3 Antibody / Calpain 3

Immunogen: A portion of amino acids 603-632 from the human protein was used as the immunogen for this CAPN3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the CAPN3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4oC for up to one month. For long term, aliquot the CAPN3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Calpain 3

Target: Calpain 3 (CAPN3)

Alternative Name: CAPN3

Background: Calpain 3 is a member of the calpain family of proteases, which are enzymes that break down proteins in the body. Unlike other calpain enzymes that are present in various tissues, Calpain 3 is predominantly found in skeletal muscle. Its main function is to regulate the turnover of muscle proteins, ensuring that they are properly maintained and repaired. One of the key roles of Calpain 3 is to maintain the structural integrity of muscle fibers. It is involved in the breakdown of damaged or misfolded proteins, preventing them from accumulating and causing muscle dysfunction. Additionally, Calpain 3 plays a vital role in muscle regeneration, helping to repair damaged fibers and promote muscle growth. Deficiencies in Calpain 3 have been linked to various muscle disorders, including limb-girdle muscular dystrophy type 2A. In individuals with this condition, mutations in the CAPN3 gene lead to impaired muscle function and weakness.

UniProt: P20807

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development