alpha 2 Macroglobulin antibody (AA 604-748)

Catalog No. ABIN7876079

This Mouse Monoclonal antibody specifically detects alpha 2 Macroglobulin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for alpha 2 Macroglobulin antibody (AA 604-748) (ABIN7876079)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This alpha 2 Macroglobulin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: A2M-3623

Product Details anti-alpha 2 Macroglobulin Antibody

Binding Specificity: AA 604-748

Purpose: A2M Antibody / Alpha-2-Macroglobulin

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 604-748 from the human protein was used as the immunogen for the A2M antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the A2M antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the A2M antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: A2M

Background: Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.

UniProt: P01023

Pathways: Lipid Metabolism