alpha 2 Macroglobulin antibody (AA 604-748)

Catalog No. ABIN7876080

The Mouse Monoclonal anti-alpha 2 Macroglobulin antibody is suitable to detect alpha 2 Macroglobulin in samples from Human. It has been validated for IHC (p).

Quick Overview for alpha 2 Macroglobulin antibody (AA 604-748) (ABIN7876080)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This alpha 2 Macroglobulin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: A2M-3621

Product Details anti-alpha 2 Macroglobulin Antibody

Binding Specificity: AA 604-748

Purpose: Alpha-2-Macroglobulin Antibody / A2M (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 604-748 from the human protein was used as the immunogen for the Alpha-2-Macroglobulin antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the Alpha-2-Macroglobulin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Alpha-2-Macroglobulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: Alpha-2-Macroglobulin

Background: Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.

UniProt: P01023

Pathways: Lipid Metabolism