AXIN2 antibody (AA 614-843)

Catalog No. ABIN7876137

The Rabbit Polyclonal anti-AXIN2 antibody is suitable to detect AXIN2 in samples from Human. It has been validated for WB, ELISA, FACS and IHC (p).

Quick Overview for AXIN2 antibody (AA 614-843) (ABIN7876137)

Target: AXIN2 (Axin 2 (AXIN2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AXIN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AXIN2 Antibody

Binding Specificity: AA 614-843

Purpose: AXIN2 Antibody / Axis inhibition protein 2

Purification: Antigen affinity purified

Immunogen: Recombinant human Axin 2/AXIN2 protein (amino acids D614-D843) was used as the immunogen for the AXIN2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the AXIN2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the AXIN2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for AXIN2

Target: AXIN2 (Axin 2 (AXIN2))

Alternative Name: AXIN2

Background: Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

UniProt: Q9Y2T1

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling