PCDHAC2 antibody (AA 616-644)

Catalog No. ABIN7876139

This Rabbit Polyclonal antibody specifically detects PCDHAC2 in WB, FACS, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for PCDHAC2 antibody (AA 616-644) (ABIN7876139)

Target: PCDHAC2 (Protocadherin alpha Subfamily C, 2 (PCDHAC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHAC2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PCDHAC2 Antibody

Binding Specificity: AA 616-644

Purpose: Protocadherin alpha-C2 Antibody / PCDHAC2

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 616-644 from the human protein was used as the immunogen for the Protocadherin alpha-C2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Protocadherin alpha-C2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Protocadherin alpha-C2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PCDHAC2

Target: PCDHAC2 (Protocadherin alpha Subfamily C, 2 (PCDHAC2))

Alternative Name: Protocadherin alpha-C2

Background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

UniProt: Q9Y5I4