RHBDD1 antibody (AA 62-293)

Catalog No. ABIN7876156

The Rabbit Polyclonal anti-RHBDD1 antibody (ABIN7876156) specifically detects RHBDD1 in WB, ELISA, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for RHBDD1 antibody (AA 62-293) (ABIN7876156)

Target: RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RHBDD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RHBDD1 Antibody

Binding Specificity: AA 62-293

Purpose: RRP4 Antibody / EXOSC2

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R62-G293) was used as the immunogen for the RRP4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RRP4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RRP4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RHBDD1

Target: RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))

Alternative Name: RRP4

Background: Exosome component 2, also known as Exosome complex component RRP4 and EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events.

UniProt: Q13868