SH3G2 antibody (AA 65-292)

Catalog No. ABIN7876278

The Rabbit Polyclonal anti-SH3G2 antibody is suitable to detect SH3G2 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, FACS, IF and IHC (p).

Quick Overview for SH3G2 antibody (AA 65-292) (ABIN7876278)

Target: SH3G2 (Endophilin-A1 (SH3G2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3G2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SH3G2 Antibody

Binding Specificity: AA 65-292

Purpose: Endophilin A1 Antibody / SH3GL2

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R65-Q292) was used as the immunogen for the Endophilin A1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Endophilin A1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Endophilin A1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SH3G2

Target: SH3G2 (Endophilin-A1 (SH3G2))

Alternative Name: Endophilin A1

Background: Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene. Endophilin proteins are part of a large family of Bin/Amphiphysin/Rvs (BAR) domain proteins that are involved in cell membrane remodeling. The endophilins are encoded by five genes, which produce endophilin A 1-3 and B 1-2. Endophilins are involved in many cellular mechanisms, such as synaptic vesicle recycling, receptor trafficking, and membrane remodeling processes. Research studies indicate that endophilin 1 (endophilin A1, SH3GL2) can induce different membrane shapes and participate in the morphogenesis of dendritic spines. Endophilin 1 is also involved in regulating blood brain barrier permeability via the EGFR-JNK pathway.

UniProt: Q99962

Pathways: Neurotrophin Signaling Pathway, EGFR Downregulation