CD86 antibody (AA 66-195)

Catalog No. ABIN7876333

The Mouse Monoclonal anti-CD86 antibody (Clone C86-3713) (ABIN7876333) specifically detects CD86 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CD86 antibody (AA 66-195) (ABIN7876333)

Target: CD86

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD86 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: C86-3713

Product Details anti-CD86 Antibody

Binding Specificity: AA 66-195

Purpose: CD86 Antibody

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 66-195 from the human protein was used as the immunogen for the CD86 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD86 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the CD86 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CD86

Target: CD86

Alternative Name: CD86

Background: Recognizes a protein of 70 kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkins disease.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation