Gasdermin A antibody (AA 66-94)

Catalog No. ABIN7876353

The Rabbit Polyclonal anti-Gasdermin A antibody is suitable to detect Gasdermin A in samples from Human and Mouse. It has been validated for WB, FACS and IHC (p).

Quick Overview for Gasdermin A antibody (AA 66-94) (ABIN7876353)

Target: Gasdermin A (GSDMA)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gasdermin A antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Gasdermin A Antibody

Binding Specificity: AA 66-94

Purpose: GSDMA Antibody / Gasdermin-A

Purification: Antigen affinity

Immunogen: A portion of amino acids 66-94 from the human protein was used as the immunogen for this GSDMA antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the GSDMA antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4oC for up to one month. For long term, aliquot the GSDMA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Gasdermin A

Target: Gasdermin A (GSDMA)

Alternative Name: GSDMA

Background: Gasdermin-A is a protein that plays a crucial role in programmed cell death, or pyroptosis, a process that is essential for the body to eliminate infected or damaged cells. This protein acts as a pore-forming molecule, causing the cell membrane to rupture and release pro-inflammatory molecules that signal the immune system to clear away the debris. Recent studies have shown that dysregulation of Gasdermin-A can lead to a variety of health issues, including autoimmune diseases, inflammatory disorders, and even cancer.

UniProt: Q96QA5