SEZ6L antibody (AA 662-953)

Catalog No. ABIN7876361

This Rabbit Polyclonal antibody specifically detects SEZ6L in WB, ELISA, FACS and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SEZ6L antibody (AA 662-953) (ABIN7876361)

Target: SEZ6L (Seizure Related 6 Homolog Like (SEZ6L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEZ6L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-SEZ6L Antibody

Binding Specificity: AA 662-953

Purpose: SEZ6L Antibody

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids E662-E953) was used as the immunogen for the SEZ6L antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SEZ6L antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SEZ6L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SEZ6L

Target: SEZ6L (Seizure Related 6 Homolog Like (SEZ6L))

Alternative Name: SEZ6L

Background: Seizure 6-like protein is a protein that in humans is encoded by the SEZ6L gene. SEZ6L (Seizure 6-Like protein, also BSRP-B in rodent) is a 200 kDa member of the SEZ6 family of proteins. It is expressed in the plasma membrane and ER of CNS neurons and lung bronchiolar epithelium, and likely regulates PKC alpha activation. Mature human SEZ6L is a 996 amino acid (aa) type I transmembrane protein. It contains a 930 aa extracellular domain (ECD) (aa 29-958) plus a 45 aa cytoplasmic tail. The ECD shows three CUB domains and five short consensus repeats (SCRs). There are multiple isoforms possible for SEZ6L. One shows a deletion of aa 933-943, and a second shows the same deletion coupled to a Thr substitution for aa 803-867. A third isoform contains a Leu substitution for aa 867-943. An alternative start site is reported at Met228. This start site may occur individually, or be accompanied by a deletion of aa 932-944, the same deletion of aa 932-944 coupled to a Thr substitution for aa 803-867, or a duel deletion of aa 869-945 and 1016-1024. Over aa 29-958, human BSRP-B is 80 % aa identical to mouse BSRP-B.

UniProt: Q9BYH1