CDK14 antibody (AA 67-96)

Catalog No. ABIN7876387

The Rabbit Polyclonal anti-CDK14 antibody (ABIN7876387) specifically detects CDK14 in WB, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CDK14 antibody (AA 67-96) (ABIN7876387)

Target: CDK14 (Cyclin-Dependent Kinase 14 (CDK14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK14 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CDK14 Antibody

Binding Specificity: AA 67-96

Purpose: CDK14 Antibody / Cyclin-dependent kinase 14 / PFTAIRE-1

Purification: SAS precipitation

Immunogen: A portion of amino acids 67-96 from the human protein was used as the immunogen for the CDK14 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the CDK14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CDK14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDK14

Target: CDK14 (Cyclin-Dependent Kinase 14 (CDK14))

Alternative Name: CDK14

Background: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. [UniProt]

UniProt: O94921