Thyroperoxidase antibody (AA 685-804)

Catalog No. ABIN7876416

The Mouse Monoclonal anti-Thyroperoxidase antibody is suitable to detect Thyroperoxidase in samples from Human. It has been validated for IHC (p).

Quick Overview for Thyroperoxidase antibody (AA 685-804) (ABIN7876416)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thyroperoxidase antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TPO-3700

Product Details anti-Thyroperoxidase Antibody

Binding Specificity: AA 685-804

Purpose: Thyroid Peroxidase Antibody / TPO (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 685-804 from the human protein was used as the immunogen for the Thyroid Peroxidase antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Thyroid Peroxidase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Thyroid Peroxidase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Alternative Name: Thyroid Peroxidase

Background: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis