Recombinant Thyroperoxidase antibody (AA 685-804)

Catalog No. ABIN7876419

The Rabbit Monoclonal anti-Thyroperoxidase antibody is suitable to detect Thyroperoxidase in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant Thyroperoxidase antibody (AA 685-804) (ABIN7876419)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Thyroperoxidase antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPO-3813R

Product Details anti-Thyroperoxidase Antibody

Binding Specificity: AA 685-804

Purpose: Recombinant Thyroid Peroxidase Antibody

Purification: Protein A affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 685-804) was used as the immunogen for this TPO antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Thyroid Peroxidase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant Thyroid Peroxidase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Alternative Name: Thyroid Peroxidase

Background: Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis