Recombinant Thyroperoxidase antibody (AA 685-804)

Catalog No. ABIN7876423

The Rabbit Monoclonal anti-Thyroperoxidase antibody (Clone TPO-6417R) (ABIN7876423) specifically detects Thyroperoxidase in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Thyroperoxidase antibody (AA 685-804) (ABIN7876423)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Thyroperoxidase antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPO-6417R

Product Details anti-Thyroperoxidase Antibody

Binding Specificity: AA 685-804

Purpose: Recombinant TPO Antibody / Thyroid Peroxidase

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 685-804 from the human protein was used as the immunogen for the recombinant TPO antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant TPO antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the recombinant TPO antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Alternative Name: TPO

Background: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

UniProt: P07202

Pathways: Thyroid Hormone Synthesis