PRELP antibody (AA 69-353)

Catalog No. ABIN7876441

The Rabbit Polyclonal anti-PRELP antibody (ABIN7876441) specifically detects PRELP in WB, ELISA and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PRELP antibody (AA 69-353) (ABIN7876441)

Target: PRELP (Proline Arginine Rich End Leucine Rich Repeat Protein (PRELP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRELP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PRELP Antibody

Binding Specificity: AA 69-353

Purpose: Prolargin Antibody / PRELP

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids I69-R353) was used as the immunogen for the Prolargin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Prolargin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Prolargin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PRELP

Target: PRELP (Proline Arginine Rich End Leucine Rich Repeat Protein (PRELP))

Alternative Name: Prolargin

Background: Prolargin is a protein that in humans is encoded by the PRELP gene. The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.

UniProt: P51888

Pathways: Glycosaminoglycan Metabolic Process