RASL12 antibody (AA 7-261)

Catalog No. ABIN7876474

The Rabbit Polyclonal anti-RASL12 antibody (ABIN7876474) specifically detects RASL12 in ELISA, WB, FACS, ICC and IF. The antibody is reactive with Human samples.

Quick Overview for RASL12 antibody (AA 7-261) (ABIN7876474)

Target: RASL12 (RAS-Like, Family 12 (RASL12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASL12 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-RASL12 Antibody

Binding Specificity: AA 7-261

Purpose: RASL12 Antibody / Ras-like protein family member 12

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human RASL12 recombinant protein (Position: K7-K261) was used as the immunogen for the RASL12 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RASL12 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RASL12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RASL12

Target: RASL12 (RAS-Like, Family 12 (RASL12))

Alternative Name: RASL12

Background: RASL12 antibody detects Ras-like protein family member 12, encoded by the RASL12 gene. Ras-like protein family member 12 is a small GTP binding protein that belongs to the Ras superfamily, which regulates signal transduction, cell growth, and cytoskeletal organization. RASL12 antibody provides researchers with a specific reagent for studying small GTPases and their influence on cellular signaling and differentiation.

Ras-like protein family member 12 is less well characterized than classical Ras proteins, but research using RASL12 antibody has shown that it retains the conserved GTP binding and hydrolysis domains characteristic of the Ras family. Through these domains, it likely regulates intracellular signaling cascades linked to growth, adhesion, and movement. Expression studies have shown that RASL12 is present in multiple tissues, suggesting broad cellular roles.

Studies with RASL12 antibody have revealed that Ras-like protein family member 12 may regulate cell cycle progression and survival pathways. Its sequence homology to other Ras proteins suggests involvement in MAPK and PI3K signaling networks, although specific effectors remain under investigation. Understanding the role of RASL12 may uncover new mechanisms of Ras family signaling and its impact on development and disease.

Dysregulation of RASL12 has been linked to tumor biology. Research using RASL12 antibody has demonstrated altered expression patterns in certain cancers, where imbalance may contribute to abnormal proliferation and survival. These findings support further investigation into its potential as a cancer biomarker and therapeutic target.

RASL12 antibody is commonly applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous expression in tissues and cell lines, immunohistochemistry reveals tissue-specific localization, and immunofluorescence highlights subcellular distribution. These approaches make RASL12 antibody valuable for research into Ras signaling networks.

By providing validated RASL12 antibody reagents, NSJ Bioreagents supports studies into Ras superfamily proteins, signal transduction, and cancer. Detection of Ras-like protein family member 12 offers researchers insight into how small GTPases integrate cellular signaling.

UniProt: Q9NYN1