CD276 antibody (AA 7-3)

Catalog No. ABIN7876479

The Mouse Monoclonal anti-CD276 antibody is suitable to detect CD276 in samples from Human. It has been validated for WB, IHC (p) and ICC.

Quick Overview for CD276 antibody (AA 7-3) (ABIN7876479)

Target: CD276

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone: 2009CT652-35-9

Product Details anti-CD276 Antibody

Binding Specificity: AA 7-3

Purpose: B7-H3 Antibody / CD276

Purification: Protein G affinity

Immunogen: Recombinant human protein was used as the immunogen for the B7-H3 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the B7-H3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the B7-H3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD276

Target: CD276

Alternative Name: B7-H3

Background: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints