Recombinant RRM1 antibody (AA 700-800)

Catalog No. ABIN7876550

This Rabbit Monoclonal antibody specifically detects RRM1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant RRM1 antibody (AA 700-800) (ABIN7876550)

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RRM1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RRM1-4372R

Product Details anti-RRM1 Antibody

Binding Specificity: AA 700-800

Purpose: RRM1 Antibody / Ribonucleotide Reductase M1

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 700-800 of human RRM1 was used as the immunogen for the RRM1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RRM1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the RRM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for RRM1

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Alternative Name: RRM1

Background: Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.

UniProt: P23921

Pathways: Positive Regulation of Endopeptidase Activity