Neuropilin 1 antibody (AA 700-900)

Catalog No. ABIN7876552

The Mouse Monoclonal anti-Neuropilin 1 antibody (Clone NRP1-4620) (ABIN7876552) specifically detects Neuropilin 1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Neuropilin 1 antibody (AA 700-900) (ABIN7876552)

Target: Neuropilin 1 (NRP1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuropilin 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NRP1-4620

Product Details anti-Neuropilin 1 Antibody

Binding Specificity: AA 700-900

Purpose: Neuropilin-1 Antibody

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein (within amino acids 700-900) from the human protein was used as the immunogen for the Neuropilin-1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Neuropilin-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Neuropilin-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Neuropilin 1

Target: Neuropilin 1 (NRP1)

Alternative Name: Neuropilin-1

Background: Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.

UniProt: O14786

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals