DKK1 antibody (AA 73-272)

Catalog No. ABIN7876677

The Rabbit Polyclonal anti-DKK1 antibody is suitable to detect DKK1 in samples from Rat and Mouse. It has been validated for ELISA and IHC (p).

Quick Overview for DKK1 antibody (AA 73-272) (ABIN7876677)

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DKK1 Antibody

Binding Specificity: AA 73-272

Purpose: Dickkopf-1 Antibody / Dkk1

Purification: Antigen affinity purified

Immunogen: Recombinant mouse protein (amino acids N73-H272) was used as the immunogen for the Dickkopf-1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Dickkopf-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Dickkopf-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for DKK1

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Alternative Name: Dickkopf-1

Background: DKK1, also called Dickkopf-1 and Dickkopf-related protein 1, is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. By genomic sequence analysis, determined that the DKK1 gene contains 4 exons. The DKK1 gene is mapped to 10q11.2 using FISH. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

UniProt: O54908

Pathways: WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation