TCF20 antibody (AA 735-1933)

Catalog No. ABIN7876697

This Rabbit Polyclonal antibody specifically detects TCF20 in WB, ICC, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for TCF20 antibody (AA 735-1933) (ABIN7876697)

Target: TCF20 (Transcription Factor 20 (TCF20))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCF20 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)

Product Details anti-TCF20 Antibody

Binding Specificity: AA 735-1933

Purpose: TCF20 Antibody / Transcription factor 20

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TCF20 recombinant protein (Position: D735-K1933) was used as the immunogen for the TCF20 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TCF20 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TCF20 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TCF20

Target: TCF20 (Transcription Factor 20 (TCF20))

Alternative Name: TCF20

Background: TCF20 antibody detects Transcription factor 20, encoded by the TCF20 gene. Transcription factor 20 is a nuclear protein that regulates gene transcription by binding to promoter regions and interacting with transcriptional co-regulators. TCF20 antibody provides researchers with a specific reagent for studying transcriptional control, development, and disease processes involving altered gene expression.

Transcription factor 20 contains multiple structural domains, including DNA-binding regions, zinc finger motifs, and protein interaction modules that allow it to function as a versatile transcriptional regulator. Research using TCF20 antibody has shown that it regulates genes involved in neuronal differentiation, immune signaling, and embryonic development. Its ability to partner with transcriptional activators and repressors highlights its broad functional repertoire.

Studies with TCF20 antibody have revealed that mutations in the TCF20 gene cause neurodevelopmental disorders characterized by intellectual disability, autism spectrum features, and hypotonia. These mutations impair transcriptional regulation, leading to widespread developmental consequences. This underscores the importance of Transcription factor 20 in brain development and function.

In addition to neurodevelopmental disorders, altered expression of TCF20 has been associated with cancer. Research using TCF20 antibody has shown that abnormal levels promote dysregulated transcriptional programs that drive proliferation and survival in certain tumor types. This suggests that TCF20 contributes to oncogenesis through transcriptional misregulation.

TCF20 antibody is widely used in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies direct DNA binding targets, western blotting quantifies expression across tissues, and immunohistochemistry reveals nuclear localization in developmental and disease contexts. These applications make TCF20 antibody valuable in both basic and clinical research.

By supplying validated TCF20 antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, neurodevelopment, and cancer. Detection of Transcription factor 20 provides researchers with insights into how transcriptional regulators control gene expression and development.

UniProt: Q9UGU0