Complement Factor H antibody (AA 751-780)

Catalog No. ABIN7876733

This Rabbit Polyclonal antibody specifically detects Complement Factor H in WB, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Complement Factor H antibody (AA 751-780) (ABIN7876733)

Target: Complement Factor H (CFH)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor H antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Complement Factor H Antibody

Binding Specificity: AA 751-780

Purpose: Complement factor H Antibody / CFH

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 751-780 from the human protein was used as the immunogen for the Complement factor H antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Complement factor H antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Complement factor H antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Complement Factor H

Target: Complement Factor H (CFH)

Alternative Name: Complement factor H

Background: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

UniProt: P08603

Pathways: Complement System, Cellular Response to Molecule of Bacterial Origin