PIK3AP1 antibody (AA 78-583)

Catalog No. ABIN7876786

The Rabbit Polyclonal anti-PIK3AP1 antibody (ABIN7876786) specifically detects PIK3AP1 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for PIK3AP1 antibody (AA 78-583) (ABIN7876786)

Target: PIK3AP1 (phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3AP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PIK3AP1 Antibody

Binding Specificity: AA 78-583

Purpose: PIK3AP1 Antibody

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids H78-R583) was used as the immunogen for the PIK3AP1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PIK3AP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PIK3AP1 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PIK3AP1

Target: PIK3AP1 (phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1))

Alternative Name: PIK3AP1

Background: Phosphoinositide 3-kinase adapter protein 1 is an enzyme that in humans is encoded by the PIK3AP1 gene. BCAP (B cell adaptor for phosphoinositide 3-kinase (PI3K)), also known as PI3KAP1, participates in linking the B cell antigen receptor (BCR) with the PI3K pathway. Tyrosine phosphorylation of BCAP by BCR-associated protein tyrosine kinases, such as Syk and Btk, generates binding sites for the p85 subunit of PI3K, resulting in activation of the PI3K pathway. Human and mouse BCAP contain 3 YXXM SH2 binding motifs for interaction with PI3K. BCAP null mice have deficient immune function, with B cells that exhibit enhanced apoptosis.

UniProt: Q6ZUJ8

Pathways: Activation of Innate immune Response, BCR Signaling, Warburg Effect