SAV1 antibody (AA 8-320)

Catalog No. ABIN7876818

The Rabbit Polyclonal anti-SAV1 antibody is suitable to detect SAV1 in samples from Human. It has been validated for WB, ELISA, IHC (p) and FACS.

Quick Overview for SAV1 antibody (AA 8-320) (ABIN7876818)

Target: SAV1 (Salvador Homolog 1 (SAV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAV1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-SAV1 Antibody

Binding Specificity: AA 8-320

Purpose: SAV1 Antibody / Protein salvador homolog 1 / WW45

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids K8-H320) was used as the immunogen for the SAV1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SAV1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SAV1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SAV1

Target: SAV1 (Salvador Homolog 1 (SAV1))

Alternative Name: SAV1

Background: Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

UniProt: Q9H4B6

Pathways: Stem Cell Maintenance