TRIP6 antibody (AA 8-476)

Catalog No. ABIN7876835

This Rabbit Polyclonal antibody specifically detects TRIP6 in WB, ELISA, IP and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TRIP6 antibody (AA 8-476) (ABIN7876835)

Target: TRIP6 (Thyroid Hormone Receptor Interactor 6 (TRIP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Product Details anti-TRIP6 Antibody

Binding Specificity: AA 8-476

Purpose: TRIP6 Antibody / Thyroid receptor-interacting protein 6

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TRIP6 recombinant protein (Position: P8-C476) was used as the immunogen for the TRIP6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TRIP6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TRIP6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TRIP6

Target: TRIP6 (Thyroid Hormone Receptor Interactor 6 (TRIP6))

Alternative Name: TRIP6

Background: TRIP6 antibody detects Thyroid receptor-interacting protein 6, a LIM domain-containing adaptor protein that links cell adhesion and cytoskeletal structures to signal transduction and transcriptional regulation. TRIP6 is part of the zyxin family of focal adhesion proteins and regulates cell motility, survival, and mechanical signaling. The TRIP6 antibody is widely used in cell signaling, cytoskeletal, and cancer biology to study focal adhesion dynamics and transcriptional control.

TRIP6 is encoded by the TRIP6 gene located on human chromosome 7q22.1. The protein is approximately 476 amino acids long and contains three LIM domains that mediate interactions with actin-associated proteins, kinases, and transcriptional regulators. TRIP6 localizes to focal adhesions, the cytoplasm, and the nucleus, reflecting its multifunctional role in signaling and structural regulation.

The TRIP6 antibody detects a 50 kilodalton band by western blot and shows strong focal adhesion staining under immunofluorescence. TRIP6 interacts with proteins such as paxillin, LPP, and integrin-linked kinase to regulate actin remodeling and cell migration. It also functions as a coactivator of transcription factors, including NF-kappaB and AP-1, linking mechanical and inflammatory signaling pathways.

In cancer, TRIP6 is frequently overexpressed and contributes to tumor cell migration, invasion, and survival. It mediates integrin and growth factor signaling, promoting metastasis through focal adhesion turnover and epithelial-to-mesenchymal transition. Conversely, in certain cell types, TRIP6 may act as a negative regulator of apoptosis and inflammation, demonstrating context-dependent roles.

As a versatile adaptor integrating cytoskeletal and transcriptional functions, TRIP6 is an important regulator of cellular mechanics and gene expression. NSJ Bioreagents provides a validated TRIP6 antibody optimized for its applications, supporting research into cell migration, mechanotransduction, and cancer progression.

UniProt: Q15654

Pathways: Cell-Cell Junction Organization